Objectives
INES is guided by a dynamic set of objectives designed to steer the exploration of positive influences on epigenetic regulation in response to the exposome, redefining the landscape of well-being research. Our objectives are as follows:
Advancement of Knowledge
We are dedicated to uncovering the intricate epigenetic imprints left by positive experiences, such as Emotional Health, Social Cohesion, Active Lifestyle, Enriching Experiences, Exposure to Natural Environments, and Workplace Satisfaction, according to their compensatory effects on negative exposures (risk factors). Through rigorous investigation, we aim to define the molecular foundations of these influences, revealing their potential in promoting well-being.
Deepening Mechanisms
Utilizing modern omics technologies alongside methodological excellence in data sciences and statistical machine learning, we strive to gain a comprehensive understanding of the mechanistic pathways underlying the effects of positive experiences on the epigenome from a systems biomedicine perspective. By doing so (in human populations and experimental models), we aim to solidify causal connections between positive influences and their impact on health outcomes.
Enrichment of Competencies
Through the development of training programs, INES is committed to nurturing a new generation of researchers equipped with a broad set of skills spanning the humanities and quantitative sciences, with a primary focus on humanity’s evolutionary biology within the environment. These programs will be designed to provide participants with the specialized expertise needed to understand and navigate the complexities of this emerging field of research.
Enhancement of Measures
From a translational research perspective, INES seeks to elevate the precision, quality, and scope of analytical methods applied to positive experience investigations by seeking new biomarkers and surrogate outcomes. Establishing a stronger and more targeted link between positive influences and health sets the stage for informed interventions promoting well-being.
Advancement of Methodology
We recognize the importance of advancing the foundational methodologies of systems biology, biostatistics, bioinformatics, and computational biology to shape algorithms/pipelines according to statistical learning theory, prioritizing result reproducibility in a sustainable/explainable artificial intelligence perspective. This commitment to methodological innovation ensures that our research remains at the forefront of scientific progress.
Development of Resources
Central to our objectives is the development of fundamental technological resources and study cohorts. By focusing on deep epigenomic profiling and the creation of a biobank, we lay the groundwork for comprehensive investigations into the molecular signatures of positive experiences.
Emergence of a New Health Culture:
In deepening the anthropological and historical understanding of human well-being with environmental sustainability, there is an urgent need to build cultural visions rooted primarily in humanism rather than technologies. This becomes an irreplaceable imperative for any scientific development program. In line with this perspective, adopting a new epistemological approach based on disciplines such as aesthetics presents a unique opportunity. This approach not only allows for the capitalization of scientific results but integrates them as cultural heritage for the communities involved, within a context of participatory research. INES recognizes this activity, known as the Third Mission, as an essential part of its commitment to development. The aesthetics of well-being emerge as a cornerstone to reconcile the Constitutional Right to Health with the vision of the Duty of Well-being, both in self-care and in caring for others. This integrated approach aims to transform health from a mere medical concept into a cultural pillar, rooted in the awareness of individual and collective responsibility for well-being.